In vitro and in vivo antifungal activity of a triadimenol compound
10.3724/SP.J.1008.2008.00813
- Author:
Xiao-Fang OUYANG
1
Author Information
1. Department of Pharmacology
- Publication Type:Journal Article
- Keywords:
Antifungal agents;
Microbial sensitivity tests;
SL-130;
Triazoles
- From:
Academic Journal of Second Military Medical University
2010;29(7):813-816
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To observe the in vitro and in vivo antifungal activity of a triadimenol compound SL-130. Methods: The M27-A project recommended by the National Committee for Clinical Laboratory Standard (NCCLS) in 1997 was used in the present study. The minimum inhibitory concentrations (MIC80) of SL-130 were determined for candidal and non-candidal strains with different susceptibilities to fluconazole. Agar disk diffusion test, time-kill curves test and mouse survival rate were employed to examine the antifungal activity of SL-130. Results: The results indicated that SL-130 had stronger in vitro antifungal activity than fluconazole, and similar in vivo activity to fluconazole. Conclusion: The structure of SL-130 is quite unique and it has in vitro and in vivo antifungal activity: further study is warranted on the compound.
