Relationship between CYP1A1 gene single nucleotide polymorphism and genetic susceptibility of renal cancer

Author: Guo-Ping WANG ¹
Author Information

1. Department of Epidemiology
Publication Type:Journal Article
Keywords: Cytochrome P450 1A1; Genetic predisposition to disease; Kidney neoplasms; Single nucleotide polymorphism
From: Academic Journal of Second Military Medical University 2010;29(8):971-974
CountryChina
Language:Chinese
Abstract: Objective: To evaluate the relationship between the polymorphism of CYP1A1 gene and the genetic susceptibility to renal cancer. Methods: A case-control study was conducted in 175 renal cancer patients and 200 healthy control subjects to investigate the role of CYP1A1 gene A4889G(M2) and C4887A(M4) polymorphisms in renal cancer. PCR-RFLP was used to identify the genotypes of polymorphism. Results: The frequencies of A4889G and C4887A genotypes were not significantly different between RCC cases and healthy controls. M2/M2 genotype was positively correlated with the incidence of renal cancer (OR=2.225 [95%CI=1.134-4.365, P=0.020]). Conclusion: M2/M2 genotype of CYP1A1 gene may be a risk factor for renal cancer.