Differences of activated brain areas during brain error-monitoring in schizophrenia patients
10.3724/SP.J.1008.2009.00048
- Author:
Yun-Xiang TANG
1
Author Information
1. Shanghai Mental Health Center
- Publication Type:Journal Article
- Keywords:
Error-monitoring;
Event-related potentials;
Low resolution electromagnetic tomography;
Schizophrenia
- From:
Academic Journal of Second Military Medical University
2010;30(1):48-52
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To study the differences of activated brain areas during brain error monitoring in schizophrenia patients. Methods: The latencies and amplitudes of error related negativity (ERN) were obtained in 16 patients with first episode schizophrenia and 25 normal controls by high-density event related potential (ERP) technique, and the activated areas were analyzed by low resolution electromagnetic tomography (LORETA). Results: The correct response rate was significantly lower in the schizophrenia participant group than in the control group (P<0.01), and the reaction periods of correct responses and incorrect responses were significantly longer in the schizophrenia group than in the control group (P<0.05, P<0.01). The ERN latencies in the schizophrenic patients were significantly longer on Cz and Pz electrodes compared with those in the control subjects (P<0.05) and ERN amplitudes were significantly smaller than those in the controls (P<0.05). The activation of insula, superior temporal gyrus, middle temporal gyrus, and inferior parietal lobule were obviously lower in the schizophrenic participants than in the controls. Conclusion: Some brain area, such as insular, may contribute to the dysfunction of error monitoring in schizophrenia patients.
