Role of GluR2-lacking AMPAR in synaptic plasticity: Recent progress
10.3724/SP.J.1008.2009.00437
- Author:
Xian-Zhao WEI
1
Author Information
1. College of Clinical Medicine
- Publication Type:Journal Article
- Keywords:
AMPA receptors;
GluR2 subunits;
Synaptic plasticity
- From:
Academic Journal of Second Military Medical University
2010;30(4):437-441
- CountryChina
- Language:Chinese
-
Abstract:
AMPARs are excitatory glutamate receptors that mediate the fast synaptic transmission. AMPARs are homo- or hetero-tetramers composed of selective combinations of four subunits: GluR1, GluR2, GluR3 and GluR4. AMPARs containing GluR2 are mainly in the central nervous system and are Ca2+ impermeable. MPARs-lacking GluR2 are Ca2+ permeable, and GluR2-lacking AMPARs are confined to certain neurons or certain physiological or pathological conditions. Recent research showed that GluR2-lacking AMPARs play special roles in the synaptic function and plasticity and transduction of local signal transduction. This paper reviews the GluR2-lacking AMPARs and their roles in the synaptic function and plasticity.
