Early treatment with high-volume hemofiltration combined with rhubarb for patients with severe acute pancreatitis
10.3724/SP.J.1008.2009.00428
- Author:
Zhong-Dong ZOU
1
Author Information
1. Research Institute of General Surgery
- Publication Type:Journal Article
- Keywords:
Cytokines;
Endotoxins;
Hemofiltration;
Mediators of inflammation;
Rhubarb;
Severe acute pancreatitis
- From:
Academic Journal of Second Military Medical University
2010;30(4):428-431
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To investigate the effect of early treatment with a combination of rhubarb and high volume hemofiltration for patients with severe acute pancreatitis(SAP). Methods: We retrospectively analyzed the 31 SAP patients, who were treated in our department between June 2005 and December 2007. Twelve patients (control group) received high-volume hemofiltration only and the other 19 patients(treatment group)received both hemofiltration and rhubarb-enchyma infused via a gastric tube for three days. The vital signs and recovery of gastrointestinal functions were observed in the two groups. The serum concentrations of tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6) and plasma endotoxin were measured in the two groups. Results: The vital signs of all the patients were stable during the treatment. The APACHE II score and serum cytokine concentrations were significantly decreased in the two groups after treatment(P<0.05), and there was no significant difference between the treatment group and the control group (P>0.05). Gastrointestinal function of the treatment group recovered earlier, with an effective rate significantly higher than that of the control group(P<0.05). The plasma endotoxin of the control group were gradually elevated during the treatment; that of the treatment group increased first and then gradually decreased; and there was significant difference between the two groups (P<0.05). Conclusion: High-volume hemofiltration can clear the plasma inflammatory mediators and cytokines. Rhubarb can improve the gastrointestinal function and decrease the plasma endotoxin level of SAP patients; early treatment with a combination of both can improve the clinical outcomes of patients.
