Role of protease activated receptor-2 in rheumatoid arthritis: Recent progress
10.3724/SP.J.1008.2009.00725
- Author:
Sui-Yi LIU
1
Author Information
1. Department of Rheumatology and Immunology
- Publication Type:Journal Article
- Keywords:
Mast cells;
Protease activated receptor-2;
Rheumatoid arthritis;
Tryptases
- From:
Academic Journal of Second Military Medical University
2010;30(6):725-726
- CountryChina
- Language:Chinese
-
Abstract:
Protease activated receptor-2 (PAR-2) is a G-protein-coupled receptor. Recent studies indicate that PAR-2 is mainly expressed in leukocytes and activated by pancreatin and (or) tryptase, which subsequently induces inflammation through degranulation of leukocytes. Activation of PAR-2 in leukocytes is possibly involved in the pathogenesis of rheumatoid arthritis.
