Expression of PIAS2 in testis tissues of patients with different pathological types of azoospermia
10.3724/SP.J.1008.2009.00780
- Author:
Zhi-Yong XIAN
1
Author Information
1. Department of Urinary Surgery
- Publication Type:Journal Article
- Keywords:
Azoospermia;
Biopsy;
Immunohistochemistry;
Male infertility;
PIAS2;
Testis
- From:
Academic Journal of Second Military Medical University
2010;30(7):780-782
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To investigate the expression of PIAS2 in the testis tissues of patients with different spermatogenic functions. Methods: Eighty testicular biopsy samples from patients with azoospermia were subjected to pathological diagnosis and were divided into the following groups according to the pathological findings: normal or basically normal spermatogenesis group (n = 40), hypo-spermatogenesis group (HS, n = 20), and sertoli cell-only syndrome group (SCOS, n = 20). Immunohistochemical method (SP) was used to examine the expression of PIAS2 in the testis tissues with different spermatogenic functions. Results: PIAS2 was strongly positive (dark brown) in the spermatogenic cells of different functions. It was weakly positive or absent in the Leydig cells and Sertoli cells. Conclusion: The status of PIAS2 in the testicular tissues is associated with the spermatogenic functions, and it may serve as a potential parameter for predicting of spermatogenic function.
