Expression of cyclooxygenase-2, urokinase plasminogen activator and thrombospondin-1 in gastric carcinoma and surrounding peripheral lymph nodes
10.3724/SP.J.1008.2009.00771
- Author:
Fu-Hua ZHANG
1
Author Information
1. Department of Gastroenterology
- Publication Type:Journal Article
- Keywords:
COX-2;
Lymph node;
Lymphatic metastasis;
Neoplasm invasiveness;
Stomach neoplasms;
TSP-1;
u-PA
- From:
Academic Journal of Second Military Medical University
2010;30(7):771-774
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To investigate the expression of cyclooxygenase-2 (COX-2), urokinase plasminogen activator(u-PA), and thrombospondin-1 (TSP-1) in gastric carcinoma and the surrounding lymph nodes, so as to discuss their roles in the invasion and metastasis of gastric carcinoma. Methods: The expression of COX-2, u-PA, and TSP-1 in the samples was examined by tissue microarray and S-P immunohistochemistry staining. Results: The positive rates of COX-2, u-PA, and TSP-1 in gastric carcinoma were 67.7%, 78.1%, and 78.6%, respectively, which were significantly higher than those in the surrounding lymph nodes (40.0%, 6.7%, and 40.0%, respectively, P<0.05). The expression of COX-2 was significantly correlated with the depth of invasion (P<0.05). The expression of u-PA was significantly correlated with lymph node metastasis and depth of invasion (P< 0.05). The expression of TSP-1 was neither correlated with lymph node metastasis nor depth of invasion (P>0.05). COX-2, u-PA, and TSP-1 expression was not significantly different between metastatic lymph nodes and corresponding gastric carcinoma. COX-2 expression was positively correlated with u-PA, and TSP-1 expression. TSP-1 expression was not correlated with u-PA expression. Conclusion: COX-2, u-PA, and TSP-1 are highly expressed in the gastric carcinoma. COX-2 expression is correlated with depth of invasion. U-PA expression is significantly related with depth of invasion and lymph node metastasis.
