Role of FOXP3 in tumor immunity
10.3724/SP.J.1008.2009.01077
- Author:
Lei XUE
1
Author Information
1. Department of Cardiothoracic Surgery
- Publication Type:Journal Article
- Keywords:
Forkhead box protein 3;
Regulatory T cell;
Tumor immunity
- From:
Academic Journal of Second Military Medical University
2010;30(9):1077-1080
- CountryChina
- Language:Chinese
-
Abstract:
FOXP3, a member of the forkhead/winged-helix family, exerts its immunosupression effect by regulating the development, differentiation and maturation of CD4+ CD25+ regulatory T cells (Treg). Treg plays an important role in immune escape mechanism in oncology research. This article reviews the expression of FOXP3 in various types of tumors and its role in tumor immunology and immunotherapy.
