Triggering receptor expressed on myeloid cells-1 and inflammation- associated diseases: Recent progress
10.3724/SP.J.1008.2009.01206
- Author:
Ai-Ping XU
1
Author Information
1. Department of Gastroenterology
- Publication Type:Journal Article
- Keywords:
Diagnosis;
Inflammation;
Neoplasms;
Therapy;
Triggering receptor expressed on myeloid cells-1
- From:
Academic Journal of Second Military Medical University
2010;30(10):1206-1209
- CountryChina
- Language:Chinese
-
Abstract:
Triggering receptor expressed on myeloid cells-1 (TREM)-1, a recently identified molecule, is involved in monocytic activation and inflammatory responses. TREM-1 is a member of natural killer cell receptor family and is expressed on neutrophils, mature monocytes and macrophages, and it can enhance the inflammatory responses mediated by Toll-like receptor-2 and -4, showing a role of inflammation promotion. Reportedly sTREM-1 was detectable in the body fluids in the presence of bacterial or fungal infection; therefore it might be used as a marker for inflammation. In addition, recombinant sTREM-1 may also be a new method for anti-inflammatory therapy. Recently, it has been found that TREM-1 not only promoted the acute inflammatory responses, but also participated in the development of chronic inflammation. This review summarizes the role of TREM-1 in the inflammation-associated dieases.
