Absorption characteristics of silybin-phospholipid complex by rat intestine
10.3724/SP.J.1008.2009.01288
- Author:
Qiu-Xia YANG
1
Author Information
1. Department of Pharmaceutics
- Publication Type:Journal Article
- Keywords:
In situ intestine perfusion;
Intestinal absorption;
Phospholipid complex;
Silybin
- From:
Academic Journal of Second Military Medical University
2010;30(11):1288-1291
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To investigate the intestinal absorption of silybin-phospholipid complex by the whole and different segments of rat's intestine. Methods: An in situ intestinal perfusion model was employed in the present research; and absorption percent and intestinal wall permeability coefficient (Ke) were taken as indices. HPLC method was used to determine the concentrations of silybin and phenol red in the perfusate to calculate the absorption indices. Results: The absorption of silybinphospholipid complex was a first-order process, about 70% of it was absorbed after 6 h, with the absorption rate constants(Ka) being (0.193 ± 0.012) h-1. The absorption rate and Ke for silybin-phospholipid complex were similar between different intestinal segments (Duodenum, Jejunum, Ileum, and Colon) (P>0.05). Conclusion, Silybin-phospholipid complex can be absorbed in the whole intestinal segments.
