The role of autophagy in maintaining pancreatic beta-cell function
10.3724/SP.J.1008.2009.01413
- Author:
Jie WU
1
Author Information
1. Department of Endocrinology
- Publication Type:Journal Article
- Keywords:
Autophagy;
Pancreatic beta-cell;
Type 2 diabetes
- From:
Academic Journal of Second Military Medical University
2010;30(12):1413-1415
- CountryChina
- Language:Chinese
-
Abstract:
Disrupted pancreatic β-cell function and decreased β-cell number are two of the main causes of type 2 diabetes mellitus. Recent studies have indicated that autophagy plays an important role in protecting pancreatic β-cell and in maintaining the structure, number, and secretive function of pancreatic β-cell. Although autophagy has been a focus of study in recent years, including areas such as tumor, neural diseases and aging, but its relationship with pancreatic β-cell was not included. In this paper we review the concept of autophagy and its role in maintaining the normal function of pancreatic β-cells.
