Vascular endothelial growth factor C, D promote formation of lymphatic vessel in esophageal squamous cell carcinoma
10.3724/SP.J.1008.2009.01406
- Author:
Xiang CAO
1
Author Information
1. Department of Cardio-thoracic Surgery
- Publication Type:Journal Article
- Keywords:
Esophageal neoplasms;
Lymphatic vessel density;
Vascular endothelial growth factors
- From:
Academic Journal of Second Military Medical University
2010;30(12):1406-1409
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To investigate the role of vascular endothelial growth factor C (VEGF-C), D (VEGF-D), and lymphatic vessel formation induced by them in the spreading of esophageal squamous cell carcinoma ( ESCC). Methods: We evaluated the expression of VEGF-C and D in 64 ESCC specimens and assessed the lymphatic vessel density (LVD) in tumor and adjacent tissues by using D2-40 immunostaining. And their relationship with the clinicopathological parameters of ESCC was analyzed. Results: The expression of VEGF-C and D was significantly higher in the tumor and adjacent tissues compared with that in the normal control tissue (P<0. 01) ,and their expression was significantly correlated with lymph node metastases (P< 0.0I), TNM stage (P<0. 05) and tumor infiltration depth (P<0. 05). LVD was significantly higher in tumor and adjacent tissues than in normal tissue (P<0. 05), but LVD was not correlated with the clinicopathological parameters, including lymph node metastasis. In addition, the LVD in the VEGF-C or VEGF-D positive groups was significantly higher than that in the negative group (P<0. 05). Conclusion: Our results suggest VEGF-C and VEGF-D expression may promote lymphangiogenesis in esophageal carcinoma, contributing to metastasis of ESCC to regional lymph node.
