Effect of rosiglitazone on bone microarchitecture of bilaterally ovariectomized rats
10.3724/SP.J.1008.2009.01402
- Author:
Sheng-Guang CHEN
1
Author Information
1. Department of Endocrinology
- Publication Type:Journal Article
- Keywords:
Bone;
Micro-CT;
Ovariectomy;
Rosiglitazone
- From:
Academic Journal of Second Military Medical University
2010;30(12):1402-1405
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To study the effect of rosiglitazone on the bone microarchitecture of bilaterally ovariectomized(OVX) rats. Methods: Twenty-one 24-week-old skeletally mature rats were bilaterally ovariectomized, and were randomly divided into three groups (n = 7) : Control group(C group) ,Rosiglitazone A group(RA group) ,and Rosiglitazone B group (RB group). Rats in RA group were given i. g 0. 35 mg/d rosiglitazone for four weeks and those in the RB group were given i. g 0. 70 mg/d rosiglitazone. Rats in the control group were given normal saline in the same manner. The rats were sacrificed four weeks later. The bone volume/tissue volume (BV/T V) , the trabecular number(Tb. N), the trabecular thickness ( Tb. Th), the trabecular separation Th. Sp), and the bone surface/bone volume (BS/BV) of the femur, tibia, and lumbar were determined by micro-computered tomography(micro-CT). Results: Compared with the control group, the Tb. N,Tb. Th, and BS/BV of the femur, tibia, and lumbar all decreased significantly in RA group (except for the BS/BV of tibia) (P<0. 05, P<0. 01) ; the Tb. SP of tibia and lumbar in the RA group were significantly increased (P<0. 05) ; and there were no differences in BV/TV between the two groups. Compared with control group, the Tb, N, Tb. Th, and BS/BV of the femur, tibia, and lumbar were decreased significantly in RB group (P<0. 05, P<0. 01); the Tb. Sp of tibia and lumbar increased significantly (P<0. 05); and the BV/TV had no differences between the two groups. There were no significant differences between the RA group and RB group concerning all the parameters. Conclusion: Rosiglitazone can cause injury to the bone microarchitecture, especially to the cancellous part of the bone.
