Antifungal activities of four triterpene glycosides derived from sea cucumber Actinopyga sp.
10.3724/SP.J.1008.2010.00521
- Author:
Hong-Wei ZHANG
1
Author Information
1. Research Center for Marine Drugs
- Publication Type:Journal Article
- Keywords:
Actinopyga sp.;
Antifungal activity;
Triterpene glycosides
- From:
Academic Journal of Second Military Medical University
2010;31(5):521-526
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To study the antifungal activities of triterpene glycosides derived from the sea cucumber Actinopyga sp. Methods: Triterpene glycosides were isolated and purified by silica gel chromatography, reversed-phase silica gel chromatography, Sephadex LH-20, and RP-HPLC from Actinopyga sp. The structures of the triterpene glycosides were elucidated based on spectral data, chemical reactions, and related references. The antifungal activities of the extracts against three strains: Candida albicans, Cryptococcus neoformans, and Aspergillus fumigatus were assessed by liquid microdilution method. Results: Four triterpene glycosides were identified from Actinopyga sp.; and they included frondoside A (1), pervicoside C (2), holothurin A (3), and holothurin B (4). The MIC80 of compound 2 and compound 3 for antifungal effect were 1-4 mg/L, showing marked antifungal activities. Conclusion: Compounds 1 and 2 have been isolated from this halobios for the first time. All the four compounds show considerable antifungal activities, and pervicoside C may be used as a lead compound of antifungal agents.
