Expression of human giant larvae-1 in ovarian cancer and its clinical significance
10.3724/SP.J.1008.2010.00513
- Author:
Yan ZHANG
1
Author Information
1. Department of Obstetrics and Gynecology
- Publication Type:Journal Article
- Keywords:
Gene expression;
Hugl-1;
In situ hybridization;
Ovarian neoplasms
- From:
Academic Journal of Second Military Medical University
2010;31(5):513-515
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To study the expression of human giant larvae-1 (Hugl-1) in ovarian carcinoma and its clinical significance. Methods: Hugl-1 mRNA expression in 31 ovarian cancer and the corresponding adjacent tissues was examined by real-time fluorescence quantitative RT-PCR and in situ hybridization. Moreover, analysis was done while taking into consideration of the clinicopathologic parameters of ovarian cancer. Results: The expression of Hugl-1 mRNA in ovarian cancer tissue was significantly higher than that in the corresponding adjacent tissues ([0.051±0.029] vs [0.026±0.043], P<0.01); and the expression was not related to patient age, serum CA125 status, pathological characteristics or clinical stages of tumors. Conclusion: Hugl-1 may play a role in the development and progresssion of ovarian cancer.
