Regulatory role of phosphatidylinositol 4,5-bisphosphate in transient receptor potential channel
10.3724/SP.J.1008.2010.00887
- Author:
Xiao-Na DU
1
Author Information
1. Department of Pharmacology
- Publication Type:Journal Article
- Keywords:
Phosphatidylinositol-4,5-diphosphate;
Regulation;
TRP channel
- From:
Academic Journal of Second Military Medical University
2010;31(8):887-891
- CountryChina
- Language:Chinese
-
Abstract:
Transient receptor potential(TRP) superfamily includes seven subfamilies and TRP channels are regulated by a wide variety of physical and chemical factors. Recently, several members of the TRP channel family have been reported to be regulated by phosphatidylinositol 4,5-bisphosphate(PIP2). The regulation is complex and it can be activation or inhibition, involving multiple mechanisms and factors. This review summarizes the PIP2 regulation of several TRP channels of different superfamilies and the related pathophysiological significance.
