Investigation of in vitro release model of injectable implants
10.3724/SP.J.1008.2010.00874
- Author:
Qing-Feng LIU
1
Author Information
1. Department of Pharmaceutical Science
- Publication Type:Journal Article
- Keywords:
In vitro;
In vivo;
Injectable implant;
Release model
- From:
Academic Journal of Second Military Medical University
2010;31(8):874-877
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To investigate the feasibility of in vitro release models of injectable implants. Methods: An RP-HPLC method was established for determination of norfloxacin (NF). The in vitro release profiles of injectable implants in four release models, including direct injection model, one-way cylinder, dialysis tube and home-made cylinder, were studied and compared with the in vivo release profiles. Results: The in vivo release of NF from injectable implants was much faster than the in vitro release of NF. The in vivo release was close to the zero-order release kinetics in the sustained release phase (1-20 d, r=0.993 5), while the in vitro release could be divided into slow phase and fast phase with 15 d as the turning point. Of the four in vitro release models, home-made cylinder showed the closest initial release to the initial release of NF in vivo. Conclusion: All the above four release models have limitations; they can not well reflect the in vivo release profiles of injectable implants; and further studies are needed for the in vitro release model of injectable implants.
