Preparation of visualized iodized oil-5-fluorouraciI loaded polylactic acid microspheres
10.3724/SP.J.1008.2010.01100
- Author:
Xin-Xia WANG
1
Author Information
1. Department of Pharmacy
- Publication Type:Journal Article
- Keywords:
Double emulsion method;
Fluorouracil;
Iodized oil;
Microspheres;
Polylactic acid
- From:
Academic Journal of Second Military Medical University
2010;31(10):1100-1103
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To prepare visualized iodized oil-5-fluorouracil loaded polylactic acid(PLA) micropheres for hepatic artery embolism treatment. Methods: Biocompatible and biodegradable material PLA was used as vector and iodized oil was used as positive contrast agent to prepare 5-fluorouracil loaded microspheres using double emulsion method. The preparation technology of the microspheres was developed through optimization of appearance, size distribution, drug loading, and encapsulation efficiency by orthogonal-designing method. Results: The prepared PLA microspheres were round in shape and had a homogenous diameter distribution. Scanning electron microscope (SEM) showed a pored surface, with an average diameter of 100 μm. The encapsulation efficiency and drug content of microspheres were (63.34%±0.54%) and (10.78%±0.14%), respectively. Conclusion: We have successfully prepared the visualized iodized oil-5-fluorouracil PLA microspheres, which can release 5-fluorouracil in a controlled manner.
