Pathological implication of postnatally up-regulated AFP expression in ZBTB20 knockout neonatal mice
10.3724/SP.J.1008.2010.01045
- Author:
Hai ZHANG
1
Author Information
1. Department of Pathophysiology
- Publication Type:Journal Article
- Keywords:
Alpha-fetoproteins;
Knockout mice;
ZBTB20;
Zinc finger protein
- From:
Academic Journal of Second Military Medical University
2010;31(10):1045-1048
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To investigate the pathological roles of postnatally up-regulated alpha-fetoprotein (AFP) expression in ZBTB20 knockout mice in postnatal growth retardation, metabolic dysfunction, and pre-mature mortality. Methods: ZBTB20 and AFP knockout mice were generated by crossbreeding ZBTB20 knockout mice with AFP knockout mice. The postnatal growth, survival rate, and blood glucose of ZBTB20/AFP double knockout mice were observed and compared with those of ZBTB20 knockout mice. Results: There were no significant differences in postnatal growth, survival, and glucose homeostasis between ZBTB20/AFP doube knockout mice and ZBTB20 knockout mice. Conclusion: The postnatally upregulated liver AFP in ZBTB20 knockout mice is not associated with the growth retardation, hypoglycemia, or pre-mature mortality.
