Effects of dexmedetomidine on blood glucose, β-endorphin, tumor necrosis factor-α and interleukin-6 in patients undergoing radical esophagectomy
10.3724/SP.J.1008.2010.01330
- Author:
Zhong-Ling XU
1
Author Information
1. Department of Anesthesia
- Publication Type:Journal Article
- Keywords:
β-endorphin;
Blood glucose;
Dexmedetomidine;
Interleukin-6;
Stress;
Tumor necrosis factor-α
- From:
Academic Journal of Second Military Medical University
2010;31(12):1330-1332
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To investigate the effects of dexmedetomidine on blood glucose, β-endorphin (β-EP), tumor necrosis factor-α(TNF-α) and interleukin-6 (IL-6) levels in patients undergoing radical esophagectomy, and to discuss the possible mechanism. Methods: Forty patients with esophageal carcinoma undergoing radical esophagectomy were randomly assigned to 2 groups: dexmedetomidine group and control group (n = 20 in each). Blood samples were taken immediately before induction of anesthesia (T0), immediately after tracheal extubation (T1), day 1 and day 2 after operation (T2, T3) for determining the levels of blood glucose, plasma β-EP and serum TNF-α and IL-6. Results: Compared with those at T0, MAP and HR at T1 were significantly elevated (P<0.05) in the control group, the blood glucose and plasma β-EP at T1-T3 were significantly increased (P<0.05), and the serum TNF-α and IL-6 at T1 and T2 were significantly elevated(P<0.05). The blood glucose, plasma β-EP, serum TNF-α and IL-6 in dexmedetomidine group had no significant changes at all time points (P>0.05), and the above parameters were significantly different between the two groups at corresponding time pionts (P< 0.05). Conclusion: Continued application of dexmedetomidine can effectively decrease the levels of blood glucose, plasma β-EP, serum TNF-α and IL-6 in patients undergoing radical esophagectomy, inhibiting the peri-operative stress response.
