Expression of plasminogen activator and plasminogen activator inhibitor in ovarian of patients with polycystic ovary syndrome
10.3724/SP.J.1008.2010.01309
- Author:
Jing-Xin SHEN
1
Author Information
1. Department of Gynecology
- Publication Type:Journal Article
- Keywords:
Ovary;
Plasminogen activator inhibitor 1;
Polycystic ovary syndrome plasminogen activator
- From:
Academic Journal of Second Military Medical University
2010;31(12):1309-1313
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To investigate the association of polycystic ovary syndrome (PCOS) with plasminogen activator (tissue-type plasminogen activator [t-PA], urokinase-type plasminogen activator [u-PA]) and plasminogen activator inhibitor-1 (PAI-1). Methods: The ovary tissues of 30 PCOS patients who were treated in our hospital from Dec. 2007 to Oct. 2008 and 20 healthy controls were collected. The expression of t-PA, u-PA, and PAI-1 was examined by immunohistochemistry method. Results: In PCOS group, the positive rates of u-PA, t-PA in the granulosa cells were 20.00% and 26.67%, and in the theca cells were 33.33% and 20.00%, respectively; in the control group, the positive rates of u-PA, t-PA in the granulosa cells were 65.00% and 75.00%, in the theca cells were 75.00% and 50.00%, respectively; and there were significant differences between the two groups (P<0.05). In PCOS group, the positive rate of PAI-1 was 56.67% in the theca cells and 63.33% in interstitial cells; in the control group, the positive rates of PAI-1 were 10.00% both in the theca cells and the interstitial cells; and there were significant differences between the two groups (P<0.05). Conclusion: The disruption of plasminogen activator system may be involved in ovulation disorder of PCOS.
