Expression of F-box/WD repeat-containing protein 7, fatty acid synthase and minichromosome maintenance protein 7 in colorectal carcinoma and the related clinical significance
10.3724/SP.J.1008.2011.00040
- Author:
Juan-Juan GENG
1
Author Information
1. Department of Oncology
- Publication Type:Journal Article
- Keywords:
Colorectal neoplasms;
FAS;
FBXW7;
Immunohistochemistry;
MCM7
- From:
Academic Journal of Second Military Medical University
2011;32(1):40-44
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To study the expression of F-box/WD repeat-containing protein 7(FBXW7), fatty acid synthase (FAS) and minichromosome maintenance protein7 (MCM7) in colorectal carcinoma and the related clinical significance. Methods: Immunohistochemistry method was used to examine the expression of FBXW7, FAS and MCM7 in the colorectal carcinoma, colorectal adenoma and para-carcinoma normal mucosa tissues. Results: The positive rates of FBXW7 in the colorectal carcinoma, adenoma and normal tissues were 58.2%, 75.0%, and 88.9%, respectively, with significant difference found between the colorectal carcinoma and normal mucosa tissues (P<0.05); and FBXW7 expression was significantly correlated with the differentiation degree(χ2=10.516, P=0.001), lymphatic metastasis (χ2=4.489, P=0.034) and the tumor size(χ2=9.974, P=0.002). The positive rates of FAS in the colorectal carcinoma, adenoma and normal tissue were 94.3%, 75.0%, and 55.6%, respectively, with significant difference found between the colorectal carcinoma and normal mucosa tissues (P<0.01); and FAS expression was significantly correlated with the patient age(χ2=7.643, P=0.006). The positive rates of MCM7 in the colorectal carcinoma, adenoma and normal tissue were 95.8%, 66.7%, and 22.2%, respectively, with the difference being significant between the three groups (P<0.01). FBXW7 expression was negatively correlated with that of FAS and MCM7(r= -0.276, P=0.008; r= -0.443, P=0.000), and FAS expression was positively correlated with MCM7 expression(r=0.228, P=0.024). Conclusion: FBXW7, FAS and MCM7 might be new markers for early diagnosis and prognosis prediction of colorectal carcinoma; they may also serve as new therapeutic targets for colorectal carcinoma.
