Experimental study of scoring model for liver cirrhosis diseases
10.3724/SP.J.1008.2011.00485
- Author:
Zheng-hua WANG
1
Author Information
1. Department of General Surgery
- Publication Type:Journal Article
- Keywords:
Evaluation model;
Experimental liver cirrhosis;
Matter-Element Analysis method
- From:
Academic Journal of Second Military Medical University
2011;32(5):485-489
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To establish a scoring model for liver cirrhosis disease (SLCD) in experimental rats, so as to provide evidence for early clinical prevention and treatment of liver cirrhosis diseases. Methods: The liver cirrhosis model was induced in rats by composite factor method. The damages of hepatic tissues and the changes of serological liver function were observed in different phases of the rat liver cirrhosis model. The SLCD formula was obtained using the Master-Element Analysis method. Results: The experimental liver cirrhosis model was successfully established in rats. The experimental rat SLCD and SLCD formula were successfully constructed using the following 6 parameters, the age, total bilirubin, albumin, prealbumin, prothrombin time-international normalized ratio, and serum creatinine. The score was expressed as the R value, which gradually decreased with the aggravation of lesion and fibrosis. R=1: the liver tissue was normal; 0.702 ≤ R < 1: there were inflammatory reaction, focal degeneration and necrosis in the liver; 0.542 ≤ R < 0.702: there was fibroplasia in the liver; 0.352 ≤ R < 0.542: pseudolobules were formed, and it was in the liver cirrhosis stage; and R<0.352: it was in the later stage of liver cirrhosis. Conclusion: The SLCD model can sensitively and accurately display the liver impairment and liver function reserve during experimental liver cirrhosis in rats. It may help the early prevention, diagnosis and treatment of the cirrhosis diseases if relevant clinical evidence is obtained.
