Histone deacetylases and autosomal dominant polycystic kidney disease
10.3724/SP.J.1008.2011.00663
- Author:
Cheng XUE
1
Author Information
1. Department of Nephrology
- Publication Type:Journal Article
- Keywords:
Autosomal dominant polycystic kidney;
Epigenetics;
Histone deacetylases
- From:
Academic Journal of Second Military Medical University
2011;32(6):663-666
- CountryChina
- Language:Chinese
-
Abstract:
Autosomal dominant polycystic kidney disease(ADPKD) is one of the most frequent inherited kidney diseases, with the incidence rate being 100-250 per 100,000. Epigenetic gene modulation and protein functions have become a focus of study for ADPKD. Evidence generated to-date indicates that one of the epigenetic modifier, histone deacetylases (HDACs), is an important regulator of ADPKD. HDACs have been involved in regulating Pkd1 gene expression. HDAC5 is the target of fiuid flow-induced calcium signal in kidney epithelial cells HDAC6 is Up-regulated in cystic epithelial calls; they can regulate ciliogenesis and epidermal growth factor receptor (EGFR) transportation through deacetylating α-tubulin and regulate Wnt Signaling through deacetylating β-catenin. HDAC inhibitors have been found to reduce cyst formation in Pkd1 conditional knockout mice and delay renal function decline n Pkd2 knockout mice, indicating a potential to serve as a new target for ADPKD therapy. This article focuses on the recent progress in research of histone deacetylation in ADPKD.
