Application of LC-MS technique in metabolite and metabonomic research of naditional Chinese medicine
10.3724/SP.J.1008.2011.00658
- Author:
Bin ZHANG
1
Author Information
1. Analysis and Testing Center
- Publication Type:Journal Article
- Keywords:
Chinese herbal drugs;
Liquidchromatography-mass spectrometry;
Metabcdites;
Metabonomics
- From:
Academic Journal of Second Military Medical University
2011;32(6):658-662
- CountryChina
- Language:Chinese
-
Abstract:
Naditional Chinese mediane (TCM) and natural products are widely metabolized inorgamsm. Due to the complexity of their metabolic pathways and multiple components, multiple targets and the overall regulation functions of TCM and natural products in organism, metabonomics have been widely applied in researches on TCM metabolites and pharmacodynamic mechanism However, metabonomics study needs the information of large amount of exgeroms and endogenous metabolites in the biological fluids, which requires more powerful analytical techniques. This paper reviewed liquid chromatography coupled with mass specnomeny (LC-MS) techniques commonly applied in TCM metabolite and metabonomics researches. We summarized and comparatively analyzed the data of 23 literatures we retrieved from Pubmed database. We focused on the advantages and disadvantages of various LC-MS techniques in TCM metaboromics studies; the advantages of UPLC-Q-TOF/MS were introduced in a detained manner, hcping to cast new lights on TCM metabonomics researches.
