Effect of estrogen and its receptors on glutamate-induced neural cell injury
10.3724/SP.J.1008.2011.00795
- Author:
Guang-Yun ZHANG
1
Author Information
1. Department of Pediatrics
- Publication Type:Journal Article
- Keywords:
Estrogen receptors;
Estrogens;
Glutamic acid;
Neural cell damage
- From:
Academic Journal of Second Military Medical University
2011;32(7):795-798
- CountryChina
- Language:Chinese
-
Abstract:
It has been proven that glutamate-induced excitatory toxicity can bring damage to nerve cells. Previous studies indicate that glutamate excitotoxicity-associated neuron damage play an important role in the pathogenesis of a number of nervous system diseases, and estrogen can protect neurons from glutamate excitotoxicity-associated neuron damage, which may be mediated by estrogen receptor. This paper reviews the latest progress regarding the protective effects of estrogen and its receptors against glutamate-induced neuron damage.
