Role of Smurf1 in bone morphogenetic protein-induced osteogenesis
10.3724/SP.J.1008.2011.00783
- Author:
Heng-Feng YUAN
1
Author Information
1. Department of Orthopedics
- Publication Type:Journal Article
- Keywords:
Bone morphogenetic proteins;
Smad proteins;
Smurf1
- From:
Academic Journal of Second Military Medical University
2011;32(7):783-785
- CountryChina
- Language:Chinese
-
Abstract:
Bone morphogenetic proteins (BMPs) are confirmed growth factors that can induce osteogenesis. They can bind to the surface receptors of target cells and activate a series of intracellular Smad proteins, which then transduct the signal into cell nuclear; and with the assistance of a series of cofactors, the osteogenic gene expression can be triggered. Endogenous Smurfl plays an inhibitory effect on the above process. This paper reviews the role of Smurf1 in bone morphogenetic protein-induced bone formation.
