Synthesis and antifungal activity of 1-(1H-1,2,4-triazole-1-yl)-2-(2,4-difluorophenyl)-3-substituted-2-propanol
10.3724/SP.J.1008.2011.00754
- Author:
Yu ZHOU
1
Author Information
1. Department of Pharmacy
- Publication Type:Journal Article
- Keywords:
Antifungal agents;
Synthesis;
Triazoles
- From:
Academic Journal of Second Military Medical University
2011;32(7):754-758
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To study the antifungal activity of triazole alcohols by introduction of n-butyl and triazole as side chains. Methods: A total of 16 compounds of 1-(1H-1, 2, 4-triazole-1-yl)-2-(2, 4-difluorophenyl)-3-substituted-2-propanol were synthesized and characterized by 1HNMR and LC-MS. The in vitro antifungal activities of the compounds were determined by tests with 8 human pathogenic fungi. Results: It was found that all the 16 title compounds exhibited antifungal activities, and compounds 7b, 7d, 7e and 7i had antifungal activities stronger than fluconazole, similar to itraconazole. Conclusion: Introduction of n-butyl and triazole side chain can confer antifungal activities to the compounds.
