Total parenteral nutrition combined with enteral nutrition in treatment of severe acute pancreatitis
10.3724/SP.J.1008.2011.00737
- Author:
Yong-Sheng ZHANG
1
Author Information
1. Department of Nutrition
- Publication Type:Journal Article
- Keywords:
Enteral nutrition;
Nutrition therapy;
Severe acute pancreatitis;
Total parenteral nutrition
- From:
Academic Journal of Second Military Medical University
2011;32(7):737-740
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To explore the therapeutic effect of total parenteral nutrition(TPN) combined with enteral nutrition (EN) in treatment of severe acute pancreatitis (SAP). Methods: A total of 126 patients with SAP were equally randomized into the following three groups: TPN group, EN group, and TPN+ EN group. Peptisorb enteral nutrition was chosen and was given by jejunostomy or nasojejunal feeding tube. The changes of clinical parameters were observed in the 3 groups. Results: The APACHE- II scores, Ranson score, and the concentration of C reactive protein were not significantly different between the 3 groups before treatment. The total bilirubin in TPN group was significantly increased after treatment (P<0.05); the curative rate, mortality rate, plasma albumin, prealbumin, urea nitrogen, creatinine, cholesterol, triacylglyceride, and blood glucose underwent no significant difference. Compared with TPN and EN groups, the TPN + EN group had a shorter hospital study, lower rate of infectious complications (P<0.05). Compared with TPN group, EN group had a significantly lower rate of infectious complications (P<0.05). Conclusion: The combined application of TPN and EN can effectively reduce complications and decrease the average hospital stay in SAP patients; the method is more suitable for SAP patients.
