Anti-LGI1 Limbic Encephalitis Presented with Atypical Manifestations.
- Author:
Jung Ju LEE
1
;
Soon Tae LEE
;
Keun Hwa JUNG
;
Kon CHU
;
Sang Kun LEE
Author Information
- Publication Type:Case Report
- Keywords: limbic encephalitis; chest pain; seizure; immune
- MeSH: Chest Pain; Diagnosis; Early Diagnosis; Female; Glioma; Humans; Limbic Encephalitis*; Memory; Middle Aged; Nervous System Diseases; Recurrence; Seizures
- From:Experimental Neurobiology 2013;22(4):337-340
- CountryRepublic of Korea
- Language:English
- Abstract: Anti-leucine-rich glioma inactivated-1 (LGI1) limbic encephalitis (LE) is a rare neurological disorder that has a subacute course of progressive encephalopathy and fasciobrachial dystonic seizures. We report a patient with anti-LGI1 LE that presented with atypical manifestations that complicated the diagnosis. A 62-year-old woman presented with a chronic course of memory disturbance and a subsequent relapse with an altered mental status after 10 months. The patient reported frequent chest pain of squeezing and dull nature, typically lasting 10-30 seconds. The chest pain was related to partial seizures, which were confirmed by video-EEG monitoring. Anti-LGI1 antibody was identified in serum and CSF. The patient's symptoms improved by immune modulation treatment. Patients with anti-LGI1 LE can experience atypical partial seizures, and a chronic relapsing course. Clinical suspicions and video-EEG monitoring are helpful for the early diagnosis and effective immune modulation.
