Glycosaminoglycans-binding cytokines and tumor
10.3724/SP.J.1008.2011.00898
- Author:
Jun-Ye XIONG
1
Author Information
1. Molecular Oncology Laboratory
- Publication Type:Journal Article
- Keywords:
Glycosaminoglycan cytokines neoplasms
- From:
Academic Journal of Second Military Medical University
2011;32(8):898-901
- CountryChina
- Language:Chinese
-
Abstract:
Glycosaminoglycans (GAGs) are a group of important large biological molecules containing a hexosamine and an uronic acid component. Glycosaminoglycans-binding cytokines, such as vascular endothelial growth factor, midkine, osteopontin, heparanase, and basic fibroblast growth factor, can be found on cell surface and extracellular matrix. Inaddition to various biological functions, GAGs-binding cytokines are also closely related totumor development and progression. GAGs-binding cytokines are gaining increasing attention in molecular diagnosis and targeted therapy of tumors.
