Association of single-nucleotide polymorphisms on chromosome 1p13 and 9p21 with acute myocardial infarction in a Chinese population: The AMI study in China
10.3724/SP.J.1008.2011.00822
- Author:
Jin GUO
1
Author Information
1. Division of Biometrics, National Center for Cardiovascular Diseases
- Publication Type:Journal Article
- Keywords:
China;
Haplotype;
Myocardial infarction;
Single-nucleotide polymorphisms
- From:
Academic Journal of Second Military Medical University
2011;32(8):822-829
- CountryChina
- Language:Chinese
-
Abstract:
Objective To determine whether the single nucleotide polymorphism (SNPs) on chromosome 9p21 and 1p13 were associated with acute myocardial infarction (AMI) in a Chinese population, and to compare the allelic frequencies of risk SNP between populations living in north east China, north China, and south east China. Methods We conducted a case control study. Cases were those developed initial AMI (n=1148) between 1999 and 2003; controls (n=1185) were randomly selected age and sex matched non cardiovascular disease patients or normal controls. Twenty SNPs sites in 6 domains (9p21,1p13, 1p32, 1q41,10q11 and 19p13) were studied using the Illumina GoldenGate technology and the Bead Studio software package. SAS /genetics, SAS /STAT and Haploview were used for result analysis and for completing the drawing. Results Four SNPs in 9p21 and 2SNPs in 1p13 were associated with AMI risk in Chinese population (Global P value formul tiple logistic regression, <0.0001), with rs10757274 showing the strongest association with AMI (P=0.006).GG carriers off our SNPs (rs10757274,rs2383206,rs10757278 and rs1333049) in 9p21 were associated with higher risk of AMI (OR=1.40, 95% CI: 1.10-1.79; OR=1.33,95% CI:1.04-1.69; OR=1.35, 95% CI:1.07-1. 72; OR=1.34,95% CI:1.06-1.71).The present study failed to find a significant association of 9 SNPs in 1p32,1q41,10q11,and 19p13 regions with AMI. In the control or cases groups, G allele frequencies of rs646776 in populations living in north and north east China were significantly higher than those living in south China (P<0.05).Conclusion SNP rs10757274 is the susceptible locus of AMI in Chinese population.
