Relationship between hepatic histopathological progression and findings of clinical noninvasive examination in patients with non-viral liver diseases
10.3724/SP.J.1008.2011.00830
- Author:
Li-Ping CHEN
1
Author Information
1. Department of Gastroenterology
- Publication Type:Journal Article
- Keywords:
Liver histopathologic progression;
Non-viral liver diseases;
Noninvasive analysis model;
Noninvasive examination
- From:
Academic Journal of Second Military Medical University
2011;32(8):830-835
- CountryChina
- Language:Chinese
-
Abstract:
Objective To elucidate the relationship between hepatic histopathologic progression and findings of clinical noninvasive examination in patients with non-viral liver diseases. Methods A total of 222patients withnon-viral liver diseases, who received liver biopsy in our hospital, were included in the present study. The association of different histopathological progression (grade of hepatic inflammation and stage of fibrosis) with the noninvasive examination parameters (serum biochemical indicators and imaging findings) was investigated. Results We found that age, serum biochemical indicators, platelet(PLT), and ratios of aspartate aminotransferase to platelet (AST/PLT), aspartate aminotransferase to alanine aminotransferase (AST/ALT) and albumin to globulin (A/G) were significantly associated with the histopathological grades and stages of hepatictissues. The grades of inflammation were markedly different between 2 groups with ALT levels higher or lower than 1 upper limits of normal (ULN)(P=0.009); the stages of hepaticfibrosis were significantly different between 2 groups with ALT levels higher or lower than 2 ULN (P=0.030).The result of B-type ultrasonic examination was positively related to the grade of hepatic inflammation and stage of fibrosis(r=0.417,P=0.000;r=0.530,P=0.000). AST/PLT and prothrombin time (PT) levelwer significantly different between patients with hepatic fibrosis and those without(P=0.015, P=0.000); AST/ALT, AST/PLT, A/G and PT levels were also significantly different between cirrhotic patients and non cirrhotic cones (P=0.042,0.012,0.000, and 0.003, respectively). The area under ROC curve of non invasive analysis model APRI was the largest one among the 3 models. APRI model had the highest sensitivity in diagnosing liver fibrosis, but with a poor specificity; S-Index had a higher specificity but a poor sensitivity. Conclusion Clinical noninvasive parameters are valuable for evaluating the activity of Hepatic inflammation and stage of fibrosis in patients with non-viral liver diseases. Noninvasive analysis model is useful for diagnosing liver fibrosis and early cirrhosis.
