A new green room temperature ionic liquid catalyzes synthesis of monastrol and its derivatives through Biginelli reaction
10.3724/SP.J.1008.2011.01019
- Author:
Wen-lin YUAN
1
Author Information
1. School of Graduate Students
- Publication Type:Journal Article
- Keywords:
1-butyl-3-methylimidazolium-L- camphorsulfonate;
Biginelli reaction;
Microwaves;
Monastrol;
Room temperature ionic liquids
- From:
Academic Journal of Second Military Medical University
2011;32(9):1019-1022
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore an easily-controllable, environmentally-friendly method for synthesizing monastrol and its derivatives. Methods Monastrol and its derivatives were synthesized using (substituted) benzaldehyde, ethyl acetoacetate and thiourea (or urea) as the material through a Biginelli reaction catalyzed by green room temperature ionic liquid 1-butyl-3- methylimidazolium-L-camphorsulfonate under microwave irradiation without solvent. Results The green room temperature ionic liquid 1-butyl-3-methylimidazolium-L-camphorsulfonate catalyzed Biginelli reaction in obtaining the title compound under microwave irradiation without solvent. The process was easy to operate, time saving and environmentally-friendly. Conclusion Microwave-accelerated solvent-free Biginelli reaction using green room temperature ionic liquid 1-butyl-3-methylimidazolium-L- camphorsulfonate as catalyst is a convenient and environmentally-friendly method for synthesizing monastrol and its derivatives.
