Changes of peripheral pain threshold in transient receptor potential vanilloid 1 knockout female mice
10.3724/SP.J.1008.2011.01013
- Author:
Qi GONG
1
Author Information
1. Department of Physiology
- Publication Type:Journal Article
- Keywords:
Knockoutmice;
Pain threshold;
TRPV cation channels
- From:
Academic Journal of Second Military Medical University
2011;32(9):1013-1015
- CountryChina
- Language:Chinese
-
Abstract:
To investigate the changes of peripheral pain threshold after knockout of transient receptor potential vanilloid l (TRPVl) gene. Methods Tail-Flick Analgesia Meterand von-Frey hair were used to determine the peripheral thermal and mechanical thresholds in TRPVl knockout and wild-type female mice, and the results of the two groups were compared. Results The Tail-Flick latency in TRPVl knockout mice was significantly prolonged after hot stimulation compared with that in the wild-type group([3.59±0.65] s vs [2.l9±0.24] s, P<0.05). There was no significant change in responses to von-Frey hair stimuli between the two groups([l.7l±0.57] g vs [2.l3±0.8l] g,P>0.05). Conclusion It is suggested that TRPVl receptor mediate thermal stimuli response under physiological condition, and has no noticeable influence on mechanical stimuli response.
