Topological properties of genetic interaction network in yeast
10.3724/SP.J.1008.2011.01009
- Author:
You-yi CUI
1
Author Information
1. Jilin Railway Vocational and Technology College
- Publication Type:Journal Article
- Keywords:
Genetic interaction;
Genomc-scale;
Topology;
Yeasts
- From:
Academic Journal of Second Military Medical University
2011;32(9):1009-1012
- CountryChina
- Language:Chinese
-
Abstract:
Objective To analyze the topological properties of genomic-wide genetic interaction network in yeast. Methods The topological properties of genomic-wide genetic interaction network in yeast were calculated by the graph theory. Results A power law fit the degree distribution well in the genomic-wide genetic interaction network in yeast, with the exponent approaching 3. TheNode's degree followed awídc-taíl distribution, with the average degree being 87. Two thirds of the genes had genetic interaction via only one gene, and about one third of the genes had genetic interaction via only 2 genes. The average clustering coefficient was 0. 047. Conclusion The gene function in yeast is usually multiple and the functional interaction between genes is highly condensed.
