Pulsed release behavior of microgels coated layer-by-layer by polyelectrolyte in vivo and in vitro
10.3724/SP.J.1008.2011.01218
- Author:
Gui-Chen ZHOU
1
Author Information
1. Department of Pharmaceutics
- Publication Type:Journal Article
- Keywords:
FITC-dextran;
Microgels;
Polyelectrolyte;
Pulsed drug deivery
- From:
Academic Journal of Second Military Medical University
2011;32(11):1218-1222
- CountryChina
- Language:Chinese
-
Abstract:
Objective To Investigate the in vitro and in vivo release of chitosan-alginate microgels coated layer-by-layer by polyelectrolyte self-assembly. Methods The cores of the microgels were made by gelatinization using electrostatic microencapsulated and coated by polyelectrolytes using electrostatic attraction. The effects of different layers and ratios of polymer on the in vitro lease of FITC-dextran were evaluated. Histrological examination was carried out to observe the in vivo release process by injecting the coated microgels into mice. Results The results showed that alginate and calcium chloride concentrations and polyelectrolyte layers markedly affected the lag time of pulsed release and the relasing speed after lagging. Conclusion The release of microgels coated layer-by-layer by polyllectrolyte can be controlled in vitro and can be observed in vivo; meanwhile, the microgels are safe and have good biocompatibility.
