Changes of peripheral pain threshold in transient receptor potential vanilloid 1 knockout female mice
- Author:
Qi GONG
1
Author Information
1. Department of Physiology
- Publication Type:Journal Article
- Keywords:
Knockoutmice;
Pain threshold;
TRPV cation channels
- From:
Academic Journal of Second Military Medical University
2011;32(10):1013-1015
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the changes of peripheral pain threshold after knockout of transient receptor potential vanilloid 1(TRPV1) gene. Methods Tail-Flick Analgesia Meterand von-Frey hair were used to determine the peripheral thermal and mechanical thresholds in TRPV1 knockout and wild-type femalemice, and the results of the two groups were compared. Results The Tail-Flick latency in TRPV1 knockout mice was significantly prolonged after hot stimulation compared with that in thewild-type group([3. 59±0. 65] s vs [2. 19±0. 24] s, P<0. 05). There was no significant change in responses to von-Frey hair stimuii between the two groups([1. 71 ±0. 57] g vs [2. 13±0. 81] g,P>0. 05). Conclusion It is suggested that TRPV1 receptor mediate thermal stimuii response under physiological condition, and has no noticeable influence on mechanical stimuii response.
