Relationship of kallikrein 3 and vitamin d receptor polymorphisms and environmental factors with prostate cancer predisposition
10.3724/SP.J.1008.2011.01310
- Author:
Lian-Sheng ZHANG
1
Author Information
1. Department of Urology
- Publication Type:Journal Article
- Keywords:
Environment;
Prostatic neoplasms;
Risk factors;
Singal nucleotide polymorphism;
Tea
- From:
Academic Journal of Second Military Medical University
2011;32(12):1310-1315
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the relationship of the single nucleotide polymorphisms (SNPs) of kallikrein 3 (KLK3) and vitamin D receptor (VDR) and environmental factors with prostate cancer predisposition in Chinese. Methods The genotypes of KLK3(rs273583 is locate between KLK an KLK) and VDR (rs731236 is located exon 9) were determined by TaqMan/MGB Probe technology in 108 prostate cancer (PCa) patients and 242 community-based normal controls. The demographic information, body mass index(BMI), smoking, alcohol consumption, tea drinking, sport activity and other environmental factors were collected for the two groups. Univariate and multivariate logistic regression models were used to assess the relationship of genetic polymorphisms and environmental risk factors with PCa. Results The frequencies of SNP rs273583 (A/G) for KLK3 AA, AG and GG genotypes were 13. 89%, 62. 96% and 23. 15% in PCa patients and 37. 19%, 44. 63%, 18. 18% in controls, respectively, with significant difference found between the two groups(P = 0. 00). The frequencies of SNPs rs731236 (T/C) for VDR TT,TC and CC genotypes were 88. 89%, 9,26%, 1. 85% in PCa patients and 90. 50%, 9. 10%, 0. 40% in controls, respectively, with no significant difference between the two groups. The study also showed that the risk for PCa in tea drinkers was only 0. 58 fold that of non-tea drinkers (QR = 0. 58,95%CI,0. 35-0. 96). Conclusion Our study indicates that tea drinking is associated with the development of PCa; tea drinking is a protective factor against PCa; SNP rs273583 o KLK i sgnificantly correlated with PCa; moreover, there is a multiplicative interaction between SNP rs273583 o KLK an environment factor. SNP rs73123 o VD i no correlate wit PCa.
