Ketamine combined with propofol in total intravenous anesthesia for spastic cerebral palsy children undergoing neural stem cell transplantation
10.3724/SP.J.1008.2012.00918
- Author:
Xiao-mei LIU
1
Author Information
1. Department of Anesthesiology, Navy General Hospital of PLA
- Publication Type:Journal Article
- Keywords:
Cerebral palsy;
Ketamine;
Propofol;
Stem cell transplantation
- From:
Academic Journal of Second Military Medical University
2012;33(8):918-920
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the safety of ketamine combined with propofol in total intravenous anesthesia for spastic cerebral palsy children undergoing neural stem cell transplantation. Methods Sixty ASA I-E spastic cerebral palsy children, aged 1-12 years old, were to undergo neural stem cell transplantation. Anesthesia was induced with propofol 1. 5-2 mg/kg and ketamine 1-2 mg/kg, iv, and maintained with target controlled infusion (TCI) of propofol 30-40 μg • kg-1 • min-1 and ketamine 10-30 μg • kg-1 • min-1. The mean arterial pressure (MAP), heart rate (HR), respiration rate (RR), and arterial oxygen saturation (Sp02) were observed during operation. The consciousness loss time, awakening time, anesthetic effect, and adverse reaction were recorded. Results There were no significant differences in MAP or HR before and after infusion. The patients had decreased RR and Sp02 at 1 min and 3 min after infusion, but there is no significant difference compared with before infusion. Consciousness loss time was (50. 5 ± 9. 1) s and the awakening time was (15. 3 ± 3. 6) min. The effect of anesthesia was satisfactory in all the children. There was no writhing, nausea, vomiting or salivating. Three cases had respiratory inhibition and one had choke cough during operation. Conclusion Ketamine combines with propofol is safe, controllable and has less side effects in total intravenous anesthesia for spastic cerebral palsy children undergoing neural stem cell transplantation.
