Alpha7 nicotinic acetylcholine receptor: A novel therapeutic target for inflammatory diseases
10.3724/SP.J.1008.2012.00897
- Author:
Ji-kuai CHEN
1
Author Information
1. Department of Pharmacology, School of Pharmacy, Second Military Medical University
- Publication Type:Journal Article
- Keywords:
Alpha 7 nicotinic acetylcholine receptor;
Cholinergic anti-inflammatory pathway;
Inflammatory diseases
- From:
Academic Journal of Second Military Medical University
2012;33(8):897-899
- CountryChina
- Language:Chinese
-
Abstract:
The cholinergic anti-inflammatory pathway (CAP) is a new neurophysiologic mechanism regulating the immune system, with alpha7 nicotinic acetylcholine receptor (α7nAChR) being its potential pharmacological target. Cumulative studies have demonstrated that activation of α7nAChR can inhibit inflammation through modulating pro-inflammatory cytokines. The role of α7nAChR has been confirmed in a series of inflammatory diseases. This review is aimed to provide new insights for using a7nAChR against inflammatory diseases.
