Effect of Shexiangbaoxin pills on heart function in patients with chronic ischemia heart failure
10.3724/SP.J.1008.2013.0037
- Author:
Ru DING
1
Author Information
1. Department of Cardiology, Changzheng Hospital, Second Military Medical University
- Publication Type:Journal Article
- Keywords:
Coronary disease;
Heart failure;
Heart function tests;
Shexiangbaoxin pills
- From:
Academic Journal of Second Military Medical University
2013;34(1):37-40
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effect of Shexiangbaoxin pills on the heart function of patients with chronic ischemia heart failure. Methods A total of 96 patients with documented stable chronic ischemia heart failure were evenly randomized into Shexiangbaoxin pill group (Shexiangbaoxin pill plus basic treatment) and placebo group (placebo plus basic treatment) for 24 weeks. The left ventricular ejection fraction (LVEF), left ventricular end diastolic volume (LVEDV), serum brain natriuretic peptide (BNP) level, and 6 minute walk test (6 MWT) were compared before and after treatment in the two groups. Results In Shexiangbaoxin pill group, the LVEF was increased by 5.6% after 24 weeks of treatment (\[34.2±3.5\]% vs \[36.1±4.0\]%, P<0.05), the serum BNP level was significantly decreased (\[680.2±203.9\] pg/mL vs \[621.8±200.7\] pg/mL, P<0.05), and the distance of 6MWT was significantly increased (\[385.3±69.2\] m vs \[401.7±75.0\] m, P<0.05); the LVEDV had no significance before and after treatment (P>0.05). The above parameters were not significantly different in placebo group before and after treatment (P>0.05). Conclusion Shexiangbaoxin pills plus basic treatment can effectively improve the left ventricular function in patients with chronic ischemia heart failure, and further study is needed to observe whether it can reverse left ventricular remodeling.
