β-arrestins in regulating inflammatory diseases: Recent progress
10.3724/sp.j.1008.2013.01237
- Author:
Mei-Jian CUI
1
Author Information
1. Department of Pharmacology, School of Pharmacy, Second Military Medical University
- Publication Type:Journal Article
- Keywords:
Inflammatory diseases;
β-arrestins
- From:
Academic Journal of Second Military Medical University
2013;34(11):1237-1242
- CountryChina
- Language:Chinese
-
Abstract:
β-arrestins, important soluble proteins mediating receptor desensitization, have diverse biological functions, such as regulating cell proliferation, cell survival, apoptosis and gene transcription. β-arrestins regulate inflammatory and immune reactions by inhibiting the basal activity of pro-inflammatory transcription factor NF-kB and participating in Toll-like receptors (TLR)/NF-kB signal pathway-mediated NF-kB activation. β-arrestins are involved in the pathogenesis of various inflammatory diseases, such as inflammatory bowel disease, rheumatoid arthritis, ankylosing spondylitis, asthma and so on. The study on β-arrestins will reveal the mechanisms of inflammatory diseases and provide new strategy for clinical treatment. Here we reviewed the recent progress on the role of β-arrestins in regulating the inflammatory diseases.
