Synthesis of three kinds of surface-modified gold nanoparticles and comparison of their stability
10.3724/SP.J.1008.2013.01214
- Author:
Fei-Fei YU
1
Author Information
1. Department of Pharmaceutics, School of Pharmacy, Second Military Medical University
- Publication Type:Journal Article
- Keywords:
Drug carriers;
Drug stability;
Gold;
Modification;
Nanoparticles
- From:
Academic Journal of Second Military Medical University
2013;34(11):1214-1219
- CountryChina
- Language:Chinese
-
Abstract:
Objective To synthesize three kinds of surface-modified gold nanoparticles and to compare their size distribution, zeta potential, surface morphology, and stability. Methods Poly (vinyl pyrrolidone) (PVP) stabilized gold nanoparticles (PVP-AuNPs), didodecyldimethylammonium bromide (DODAB, a cationic lipid) coated gold nanoparticles (DODAB-AuNPs), and cysteamine modified gold nanoparticles (CA-AuNPs) were successfully synthesized by chemical reduction method. The size distribution, zeta potential, and surface morphology of the three kinds of gold nanoparticles were characterized by dynamic light scattering (DLS) and transmission electron microscopy (TEM); and the stability of them was evaluated in various concentrations of sodium ions (0. 01, 0 1, 0. 5 and 1 mol/L NaCl; pH = 7. 2) and at different pH values (1. 0-14. 0) by UV-Vis absorption spectra. Results The mean diameters of PVP-AuNPs, DODAB-AuNPs, and CA-AuNPs were (15 0 + 3.1) nm, (22.7 + 6.1) nm, and (18. 0 + 4. 6) nm, respectively; and their zeta potentials were (- 19. 7 + 4. 1), (62. 8 + 4. 3), and (33. 3 + 7. 7) mV, respectively. It was also found that PVP-AuNPs and DODAB-AuNPs were very stable in NaCl solution and different pH environments. However, CA-AuNPs solution was sensitive to concentration of sodium ions and pH value changes and it could maintain stable only when the concentration of NaCl was 0. 01 mol/L or the pH value was within 4. 5-6. 5; otherwise there would be aggregation. Conclusion The three kinds of gold nanoparticles have a nano spherical shape and good stability, with different surface potentials when modified with different ligands; these findings provide reference for design of drug delivery carriers.
