Expressions of beclinl and microtubule-associated protein 1 light chain 3(LC3) in type a aortic dissection tissues
10.3724/SP.J.1008.2013.00946
- Author:
Yang-Feng TANG
1
Author Information
1. Department of Cardiothoracic Surgery, Changhai Hospital, Second Military Medical University
- Publication Type:Journal Article
- Keywords:
Aorta;
Autophagy;
Beclinl;
Dissecting aneurysm;
Microtubule-associated protein 1 light chain 3;
Vascular smooth muscle cells
- From:
Academic Journal of Second Military Medical University
2013;34(9):940-945
- CountryChina
- Language:Chinese
-
Abstract:
To explore the expressions of Beclinl and microtubule-associated protein 1 light chain 3(1X3) in type A aortic dissection (AD) tissue and to discuss the relevance. Methods Twenty surgical AD specimens were used in this study, and 10 normal control specimens were obtained from autopsy. Immuno-histochemical staining and Western blotting analysis were performed to evaluate the locations and expressions of Beclinl and LC3 proteins. Results It was found that Beclinl and LC3 proteins were mainly located in the vascular smooth muscle cells of the AD tissues, and the expressions in the AD tissues were signicantly higher than those in the control group (P<0. 05). Conclusion Autophagy is activated in the vascular smooth muscle cells of AD tissues, which may play an important role in the development and progression of thoracic aortic dissection.
