MicroRNAs in inflammatory response and their regulatory role in TLR signaling pathway
10.3724/SP.J.1008.2013.00782
- Author:
Jing FANG
1
Author Information
1. Institute of Radiation Medicine, Academy of Military Medical Sciences
- Publication Type:Journal Article
- Keywords:
Inflammation;
Micrornas;
NF-κB;
Toll-like receptors
- From:
Academic Journal of Second Military Medical University
2013;34(7):782-786
- CountryChina
- Language:Chinese
-
Abstract:
MicroRNAs (miRNAs) play important roles in regulating inflammatory responses, and the related mechanism and regulation characteristics are unique in immunesystem. In recent years, a large number of studies have showed that miRNAs can target mRNAs of many target genes in Toll-like receptor/nuclear factorκB(TLR/NF-κB)signaling pathway, and play regulatory roles in immune recognition and inflammatory responses. In this paper we reviewed the characteristics of miRNA in inflammatory reactions, with special attention on the regulatory roles in TLR/NF-κBsignaling pathway.
