Long noncoding RNAs in liver diseases: Recent progress
10.3724/SP.J.1008.2013.00322
- Author:
Pei-Yi LIN
1
Author Information
1. Department of General Surgery, Xinhua Hospital, Shanghai Jiaotong University School of Medicine
- Publication Type:Journal Article
- Keywords:
Hepatitis B;
Hepatocellular carcinoma;
Liver regeneration;
Long noncoding RNAs
- From:
Academic Journal of Second Military Medical University
2013;34(3):322-327
- CountryChina
- Language:Chinese
-
Abstract:
Long noncoding RNAs (lncRNAs) are RNA transcripts longer than 200 nt with no protein coding capacity. LncRNAs regulate gene expression at the epigenetic, transcriptional and post-transcriptional levels, and they are deeply involved in biological and pathological changes. Recent evidences have shown changed expression of lncRNAs in viral hepatitisand hepatocellular carcinoma, and that they play important roles in the development, progression and prognosis of hepatic cancer. This review focuses on the mechanism of lncRNAs in hepatocellular carcinoma and other liver diseases.
