Correlation of preoperative guanylate cyclase C mRNA in peripheral blood with postoperative gastric cancer recurrence
10.3724/SP.J.1008.2014.01387
- Author:
Wen XU
1
Author Information
1. Health Department of Nan tong University
- Publication Type:Journal Article
- Keywords:
Guanylate cyclase C;
Recurrence;
Stomach neoplasms;
Survival analysis
- From:
Academic Journal of Second Military Medical University
2014;35(12):1387-1390
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the correlation of preoperative guanylate cyclase C (GC-C) mRNA in peripheral blood with postoperative gastric cancer recurrence. Methods The preoperative blood samples were collected from 60 patients with gastric cancer (GC) before operation, also from 21 patients with dysplasia, 15 with intestinal metaplasia, and 20 healthy volunteers during the same period. GC-C mRNA in the peripheral blood samples was assessed by real-time fluorescent quantitative PCR (RFQ-PCR). The association of peripheral blood GC-C mRNA expression with pathological parameters and gastric cancer recurrence was analyzed. Results The positive rate of preoperative GC-C mRNA in blood samples of gastric cancer patients (48. 3% [29/60]) was significantly higher than that of patients with dysplasia (20. 0%[3/21], P
