Molecular target for treatment of non-alcoholic fatty liver disease
10.3724/SP.J.1008.2014.00657
- Author:
Yue-Ye HUANG
1
Author Information
1. Department of Endocrinology and Metabolism, The 10th-People' Hospital of Shanghai, Tongji University School of Medicine
- Publication Type:Journal Article
- Keywords:
Mitochondria;
Molecular mechanisms;
Non-alcoholic fatty liver;
Transcription factors
- From:
Academic Journal of Second Military Medical University
2014;35(6):657-661
- CountryChina
- Language:Chinese
-
Abstract:
Non-alcoholic fatty liver disease (NAFLD) is on a rise and until now there has been no effective treatment. Recent researches have mainly focused on molecular mechanisms of NAFLD and metabolic disorders, involving studies on pregnane X receptor (PXR),forkhead box protein 01 (FOXO1), farnesoid X receptor (FXR),peroxisome proliferator-activated receptors (PPARs), thyroid hormone receptor (THR), AMP-activated protein kinase (AMPK), p53, nuclear erythroid 2-related factor 2 (Nrf2), mitochondria, cannabinoid receptors, and bile-acid receptor. This review focused on these molecular mechanisms and discussed the potential values of the above targets for treatment of NAFLD.
